Please keep in mind most of the studies here are showing great results with simply topical applications. You can safely use HA injections under a qualified doctor’s supervision but you can get all the benefits of HA and other key peptides with topicals, too. Apply twice a day to wet skin or put a small amount on the back or side of your hand, and mix with an equal amount of water. These serums are very concentrated and adding a very small amount of water will help activate them for best results. Apply to the areas you desire to see results according to the serum you choose! But one thing we do know: use these before you contemplate surgery or Botox treatment. You will be amazed at the fact that you probably won’t need either!